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PARP-1 antisense ODN significantly reduced the basal and TGF-β1–induced CCN2 promoter activities of p-483CCN2L containing an intact PBE site (the −455- to −434-bp CCN2 promoter fragment), but PJ34 was without effects. In contrast, promoter activities of p-483mPBEL and p-434CCN2L, both of which lacked an intact PBE site and reactions to rhTGF-β1 treatment, were not affected by either PARP-1 antisense ODN or PJ34. The data were obtained from four independent experiments.
