Skip to main content
. 2008 May;19(5):923–932. doi: 10.1681/ASN.2007090982

Figure 1.

Figure 1.

Dependence of cisplatin nephrotoxicity on TLR4. (Top) Effect of cisplatin on renal function in C57BL/6 (▪) or Tlr4(−/−) (•) mice. Male mice were injected with saline (▴) or 20 mg/kg cisplatin (▪, •). Blood urea nitrogen and creatinine were measured at the indicated time points. *P < 0.05 versus C57BL/6 cisplatin-injected mice; n = 4 to 7. (Bottom) Effect of cisplatin on kidney morphology in C57BL/6 (A and C) and Tlr4(−/−) mice (B and D). Kidneys were removed 72 h after injection with cisplatin (A and B) or saline (C and D). Sections were stained with PAS (original magnification ×40). Wild-type mice exhibit severe tubular necrosis, tubular dilation, and cast formation throughout the cortex. Tlr4(−/−) mice have relatively well-preserved renal morphology.