Table 2.
Phenotype analysis of wild-type, Ins2Akita, and Spp1−/− Ins2Akita micea
| Group | n | Age (wk) | Body Weight (g) | Blood Glucose (mg/dl) | Albumin/Creatinine (μg/mg) |
|---|---|---|---|---|---|
| C57/B6 | 10 | 16 | 31.0 ± 1.0 | 204.0 ± 14.0 | 9.0 ± 4.0 |
| Akita | 10 | 16 | 24.0 ± 2.0 | 559.0 ± 40.0b | 438.0 ± 98.0b,c |
| Spp1−/− | 8 | 16 | 31.0 ± 1.0 | 246.0 ± 20.0 | 17.0 ± 6.0 |
| Spp1−/− Akita | 9 | 16 | 26.0 ± 2.5 | 575.0 ± 25.0b | 82.0 ± 8.0b |
a
Body weight, blood glucose, and albuminuria were measured at the time animals were killed, at 16 wk of age. Albuminuria was measured by murine albumin-specific ELISA kit and creatinine with colorimetric reaction and expressed as μg albumin/mg creatinine.
b
Statistically significant difference, P < 0.05 versus C57/B6 control groups.
c
Statistically significant difference, P < 0.05 Akita versus Spp1−/− Akita mice.