Figure 4.

STZ toxicity studies in Nephrin-CFP-Tg mice. (A) E16 kidney isolated from pregnant mice with three different maternal hyperglycemic levels after 3 d of STZ administration (150 mg/kg, intraperitoneally, at E13): Normal (6.0 mmol), mild (14.3 mmol), and severe (24.9 mmol). (B) E16 kidneys isolated from pregnant mice in normal maternal glucose range with or without administration of STZ at E13. (C) E16 and E18 kidneys isolated from pregnant mice with normal maternal glucose level with STZ administration at E13.