Figure 2.

Active-site architecture of HvTrxh1 (A) and HvTrxh2 (B). Carbon, nitrogen, oxygen, and sulfur atoms are colored green, blue, red, and yellow, respectively. The 2F _o–F _c electron density maps are presented as a gray isosurface mesh at the 1.0σ level. The water molecule buried in the internal cavity is shown as a sphere and is modeled in two alternative positions in HvTrxh1. For the HvTrxh2 structure, Cys46 and Cys49 are shown only in the reduced conformations, although they are also modeled in the oxidized conformations.