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Interaction of loop C and helix E. Detail from the structure of SoPIP2;1 illustrating how loop C and residues in helix E interacts via H-bonds. In XIPs N153 and S226 are replaced by cysteins suggesting a covalent linkage between loop C and helix E. Oxygens of water molecules at the ar/R region are represented by spheres and the discussed residues are depicted by sticks.
