Table 2.
Association analyses of CAPN1 polymorphisms with carcass traits (CW and MS) among Korean native cattle
| Genotype | ||||||||
| Trait | Polymorphism | Position | Amino acid change | C/C | C/R | R/R | P | Pcor. |
| N(LSMEAN ± SE) | N(LSMEAN ± SE) | N(LSMEAN ± SE) | ||||||
| CW | c.579G>A | Exon5 | K193K | 187(309.56 ± 2.58) | 177(311.93 ± 2.57) | 53(314.91 ± 4.99) | 0.33 | NS |
| c.630A>G | Exon6 | T210T | 174(312.17 ± 2.61) | 180(311.14 ± 2.53) | 67(310.88 ± 4.20) | 0.16 | NS | |
| c.760-24T>C | Intron6 | . | 210(312.93 ± 2.24) | 161(306.26 ± 2.72) | 43(319.27 ± 4.92) | 0.11 | NS | |
| c.843+330A>G | Intron7 | . | 224(312.42 ± 2.21) | 156(306.68 ± 2.65) | 31(323.82 ± 6.18) | 0.69 | NS | |
| c.1199G>A | Exon11 | R400Q | 417(311.43 ± 1.50) | 3(294.47 ± 19.76) | . | 0.46 | NS | |
| c.1588G>A | Exon14 | V530I | 289(311.78 ± 1.93) | 111(309.62 ± 3.27) | 15(311.41 ± 9.12) | 0.84 | NS | |
| c.1611+104C>T | Intron14 | . | 227(311.32 ± 2.26) | 155(311.06 ± 2.74) | 33(313.20 ± 5.98) | 0.88 | NS | |
| c.1869+235C>G | Intron18 | . | 128(313.33 ± 3.15) | 189(308.92 ± 2.50) | 102(312.55 ± 3.23) | 0.73 | NS | |
| c.2151*479C>T | 3'UTR | . | 342(311.37 ± 1.78) | 65(304.72 ± 4.80) | 5(321.32 ± 16.27) | 0.49 | NS | |
| c.2151*765A>G | 3'UTR | . | 307(310.08 ± 2.01) | 96(310.63 ± 4.15) | 12(311.52 ± 11.10) | 0.23 | NS | |
| c.2151*832G>A | 3'UTR | . | 335(311.67 ± 1.75) | 75(309.30 ± 4.14) | 4(315.85 ± 19.01) | 0.84 | NS | |
| c.2151*845A>G | 3'UTR | . | 293(308.97 ± 2.07) | 112(312.82 ± 3.75) | 12(317.88 ± 10.33) | 0.11 | NS | |
| Block2_ht2 | . | . | 300(310.77 ± 1.86) | 95(314.78 ± 3.50) | 15(300.73 ± 8.72) | 0.85 | NS | |
| Block2_ht3 | . | . | 335(310.25 ± 1.80) | 72(316.69 ± 4.68) | 3(303.60 ± 20.41) | 0.46 | NS | |
| MS | c.579G>A | Exon5 | K193K | 187(2.10 ± 0.10) | 177(2.39 ± 0.10) | 53(2.00 ± 0.19) | 0.85 | NS |
| c.630A>G | Exon6 | T210T | 174(2.19 ± 0.10) | 180(2.29 ± 0.10) | 67(2.09 ± 0.17) | 0.64 | NS | |
| c.760-24T>C | Intron6 | . | 210(2.18 ± 0.09) | 161(2.26 ± 0.11) | 43(2.16 ± 0.20) | 0.69 | NS | |
| c.843+330A>G | Intron7 | . | 224(2.18 ± 0.09) | 156(2.21 ± 0.11) | 31(2.16 ± 0.25) | 0.78 | NS | |
| c.1199G>A | Exon11 | R400Q | 417(2.21 ± 0.06) | 3(1.77 ± 0.79) | . | 0.47 | NS | |
| c.1588G>A | Exon14 | V530I | 289(2.21 ± 0.08) | 111(2.24 ± 0.13) | 15(2.12 ± 0.37) | 0.60 | NS | |
| c.1611+104C>T | Intron14 | . | 227(2.19 ± 0.09) | 155(2.17 ± 0.11) | 33(2.56 ± 0.24) | 0.22 | NS | |
| c.1869+235C>G | Intron18 | . | 128(2.30 ± 0.13) | 189(2.23 ± 0.10) | 102(2.12 ± 0.13) | 0.09 | NS | |
| c.2151*479C>T | 3'UTR | . | 342(2.34 ± 0.07) | 65(1.56 ± 0.19) | 5(0.94 ± 0.65) | 0.0007 | 0.02 | |
| c.2151*765A>G | 3'UTR | . | 307(2.19 ± 0.08) | 96(2.33 ± 0.17) | 12(2.67 ± 0.45) | 0.08 | NS | |
| c.2151*832G>A | 3'UTR | . | 335(2.20 ± 0.07) | 75(2.31 ± 0.17) | 4(1.10 ± 0.76) | 0.13 | NS | |
| c.2151*845A>G | 3'UTR | . | 293(2.15 ± 0.08) | 112(2.42 ± 0.15) | 12(2.77 ± 0.41) | 0.06 | NS | |
| Block2_ht2 | . | . | 300(2.11 ± 0.07) | 95(2.56 ± 0.14) | 15(2.20 ± 0.35) | 0.28 | NS | |
| Block2_ht3 | . | . | 335(2.14 ± 0.07) | 72(2.54 ± 0.19) | 3(2.28 ± 0.82) | 0.21 | NS | |
Genotype and haplotype distributions and P-values controlling for sire and age at slaughter as covariates are shown.
C/C, C/R, and R/R represent the common allele, and heterozygotes and homozygotes for the rare allele, respectively.
N(LSMEAN ± SE): Number of animals (least square mean of values ± standard errors).
Pcor. represents the simple corrected P-value (Bonferroni correction).
Significant associations are shown in boldface. NS: not significant