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. 2008 May 20;6(5):e128. doi: 10.1371/journal.pbio.0060128

Figure 6. A Proposed Model for Regulation of Draf by Src64B.

Figure 6

Inactive Raf assumes a folded or “closed” conformation due to association of the N-terminal regulatory domains with the C-terminal kinase domain. Binding to Ras-GTP transiently dissociates the N-terminus from the C-terminus, forming to an “open” conformation and exposing Y510. Subsequent phosphorylation of Y510 by Src prevents the re-association of the N- and C-termini, stabilizing the “open” conformation of Raf, allowing its further modification or association with other proteins.