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. Author manuscript; available in PMC: 2009 May 1.
Published in final edited form as: Alcohol. 2008 May;42(3):191–197. doi: 10.1016/j.alcohol.2008.01.007

Figure 1.

Figure 1

Effect of the selective mGluR2/3 agonist LY379268 on handling-induced convulsions (HIC) during ethanol withdrawal. Mice were subjected to four consecutive cycles of 16 hr of ethanol vapor inhalation, each followed by 8 hr of withdrawal. HIC assessment was performed hourly for 10 hr during the final (fourth) withdrawal period. Vehicle or drug treatments were administered at hours 4 and 8 in both ethanol-exposed mice (A) and air-exposed mice (B). HIC values at the time points following administration of LY379268 are shown in (C). Data are presented as mean ± SEM. Samples sizes are n=7-8 per treatment group in ethanol-exposed animals and n=4 per treatment group in air-exposed animals. Absence of error bars in panel C indicates the SEM values were equal to zero.