TABLE 1.
Raft components related to Alzheimer's disease
| Components | Tissues/cells | References |
|---|---|---|
| GM1 | Synaptosomes in apoE-knock-in | 42 |
| Mouse brain | ||
| Plasma membrane | 125 | |
| Rat kidney | 127 | |
| GM1, GM3, and globoside | Neuro2a cells | 111 |
| GM1 and GD3 | Rat cerebeller granule neurons and cerebellum | 120 |
| GM1 and GM2 | AD brain | 124 |
| Fucogangliosides | PC12 cells | 105 |
| Ceramide | LA-N-5, F11, and HOG cells | 126 |
| Ceramidase | Rat kidney | 127 |
| Ceramidase and sphingomyelinase | LA-N-5, F11, and HOG cells | 126 |
| Sialidase | Plasma membrane | 125 |
| Sialidase (Neu3) | HeLa cells, COS-1 cells | 128 |
| Amyloid β-precursor protein (APP) | Rat brain | 129 |
| Cerebral cortex of AD brain | 130 | |
| Madin-Darby canine kidney and P19 cells | 131 | |
| Neuro2a cells | 132 | |
| BASE1-HEX cells | 133 | |
| APP-transfected cells | 134 | |
| AD brain | 135 | |
| SH-SY5Y neuroblastma cells | 136 | |
| C2C12 cells | 137 | |
| APP C-terminal fragments (CTF2) | Mouse brain | 138 |
| APP-transfected cells | 134 | |
| APP N-terminal fragments (sAPP) | Epithelial cells | 139 |
| Amyloid β-protein (Aβ) | Rat brain | 129 |
| SH-SY6Y neuroblastma cells | 140 | |
| Tg2576-transgenic mouse (AD) | 141 | |
| Aβ dimers | Tg2576-transgenic mouse (AD) | 141 |
| Aβ oligomers | C2C12 cells | 137 |
| β-secretase (BACE1; Asp2) | Tg2576-transgenic mouse (AD) | 141 |
| SH-SY5Y neuroblastma cells | 145 | |
| SH-SY5Y neuroblastma cells | 146 | |
| Mouse embryonic fibroblasts | 21 | |
| BASE1-HEX cells | 133 | |
| A high-molecular-weight complex of BACE | AD brain | 135 |
| α-Secretase | COS7 transfectants | 142 |
| CHO transfectants | 143 | |
| Neuro2a cells transfected with PSEN1 | 144 | |
| Mouse brain | 138 | |
| γ-Secretase (PSEN1, presenilin 1) | Rat brain | 129 |
| Cerebral cortex of AD brain | 147 | |
| APP-transfected cells | 134 | |
| BASE1-HEX cells | 133 | |
| Mouse brain | 138 | |
| ApoE | Tg2576-transgenic mouse (AD) | 141 |
| Tau | Tg2576-transgenic mouse (AD) | 141 |
| Plasmin | Hippocampal neurons of AD brain | 148 |
| Rat hippocampal neurons | 149 | |
| Heparan sulfate proteoglycans (Glypican 1) | SH-SY5Y neuroblastoma cells | 136 |
ApoE, apolipoprotein E.