TABLE 3.
A pleiotropic QTL on baboon chromosome 19 (PHA19) influencing variation in Lp-PLA2 activity and LDL-C concentration in pedigreed baboons on HCHF diet
| Lp-PLA2, LDL-C | |
|---|---|
| LOD | 3.13 |
| Genome-wide P value | 0.019 |
| Baboon chromosome (PHA) | 19 |
| Location in baboon linkage map (cM from pter-most marker locus) | 40 |
| QTL-specific heritability (Lp-PLA2, LDL-C) | 0.19, 0.21 |
| ρQ | 0.99 |
| P[ρQ = 0] | 0.0000462 |
| P[ρQ = 1] | 0.44 |
| Orthologous human chromosome (HSA) | 19 |
| Marker loci used to interpolate support interval for QTL | D19S226, DM |
| Region in humans corresponding to QTL support interval | 19q12–q13.2 |
| Region in humans corresponding to maximum LOD in baboons | 19q12–q13.12 |
LOD, logarithm of odds; QTL, quantitative trait locus. Summary of bivariate linkage analysis results.