TABLE 1.
Expression profile of angiogenesis-related genes in HUVECs treatment with MCP-1- and MCPIP-specific siRNA + MCP-1
|
Gene name
|
Fold inductiona
|
|
|---|---|---|
| MCP-1 | siRNA + MCP-1 | |
| Angiopoietin-like 3 | 10.0 | |
| Angiopoietin-like 4 | 5.0 | |
| Cadherin 5 | 5.0 | |
| CD13/Gp156 | 5.0 | |
| Chemokine (CXC motif) ligand 11 | 5.0 | 2.4 |
| Shingolipid G-protein-coupled receptor 1 | 5.0 | 2.4 |
| Endoglin | 5.0 | |
| Laminin α5 | 5.1 | 2.1 |
| TIMP-1 | 4.7 | |
| Endostatin | 4.6 | |
| Prostaglandin-endoperoxide synthase 1 | 4.6 | 5.0 |
| Akt-1 | 4.3 | 2.4 |
| PECAM-1 | 4.2 | |
| Tie-1 | 4.2 | |
| VEGF-C | 4.1 | |
| Thrombospondin-1 | 4.1 | 2.5 |
| MMP-2 | 3.9 | 2.0 |
| VEGF-B | 3.5 | |
| ECGF-1 | 3.5 | 3.5 |
| Chemokine (CXC motif) ligand 10 | 3.4 | 4.7 |
| TEK tyrosine kinase | 3.2 | 2.1 |
| Angiopoietin 1 | 3.2 | |
| Platelet-derived growth factor α | 3.1 | 2.0 |
| Collagen type IV-α3 | 3.0 | |
| Interleukin 8 | 2.7 | |
| Ephrin A2 | 2.5 | |
| Jagged 1 | 2.3 | 2.2 |
| Chemokine (CXC motif) ligand 2 | 2.2 | 2.4 |
| Kinase insert domain receptor | 2.1 | |
| Urokinase | 2.1 | |
| Chemokine (CXC motif) ligand 1 | 2.0 | |
| Epidermal growth factor | 2.0 | |
a
Only genes whose expression was induced at least 2.0-fold are included. Most of angiogenesis-related genes-induced by MCP-1 were suppressed by MCPIP-specific siRNA