TABLE 1.
Gene name
|
Fold inductiona
|
|
---|---|---|
MCP-1 | siRNA + MCP-1 | |
Angiopoietin-like 3 | 10.0 | |
Angiopoietin-like 4 | 5.0 | |
Cadherin 5 | 5.0 | |
CD13/Gp156 | 5.0 | |
Chemokine (CXC motif) ligand 11 | 5.0 | 2.4 |
Shingolipid G-protein-coupled receptor 1 | 5.0 | 2.4 |
Endoglin | 5.0 | |
Laminin α5 | 5.1 | 2.1 |
TIMP-1 | 4.7 | |
Endostatin | 4.6 | |
Prostaglandin-endoperoxide synthase 1 | 4.6 | 5.0 |
Akt-1 | 4.3 | 2.4 |
PECAM-1 | 4.2 | |
Tie-1 | 4.2 | |
VEGF-C | 4.1 | |
Thrombospondin-1 | 4.1 | 2.5 |
MMP-2 | 3.9 | 2.0 |
VEGF-B | 3.5 | |
ECGF-1 | 3.5 | 3.5 |
Chemokine (CXC motif) ligand 10 | 3.4 | 4.7 |
TEK tyrosine kinase | 3.2 | 2.1 |
Angiopoietin 1 | 3.2 | |
Platelet-derived growth factor α | 3.1 | 2.0 |
Collagen type IV-α3 | 3.0 | |
Interleukin 8 | 2.7 | |
Ephrin A2 | 2.5 | |
Jagged 1 | 2.3 | 2.2 |
Chemokine (CXC motif) ligand 2 | 2.2 | 2.4 |
Kinase insert domain receptor | 2.1 | |
Urokinase | 2.1 | |
Chemokine (CXC motif) ligand 1 | 2.0 | |
Epidermal growth factor | 2.0 |
Only genes whose expression was induced at least 2.0-fold are included. Most of angiogenesis-related genes-induced by MCP-1 were suppressed by MCPIP-specific siRNA