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Coupling and uncoupling changes in CYP2C9 catalysis with the drugs diclofenac (●) (200 μM), (S)-flurbiprofen (▽) (100 μM), and (S)-warfarin (■) (100 μM) induced by alternate cyt b5 concentrations. (A) reaction coupling to drug metabolite formation (metabolite formation rate/NADPH consumption rate). (B) reaction uncoupling to H2O2 (H2O2 formation rate/NADPH consumption rate).
