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. Author manuscript; available in PMC: 2008 Jul 1.
Published in final edited form as: Drug Metab Dispos. 2007 Apr 19;35(7):1174–1181. doi: 10.1124/dmd.107.014910

Fig. 4.

Fig. 4

Combined effects of CPR and cyt b5 concentration on the metabolism of (S)-flurbiprofen to 4′-OH-flurbiprofen and H2O2 formed as a result of catalytic uncoupling (CYP2C9 = 100 nM). (A) rate of 4′-OH-flurbiprofen formation. (B) rate of H2O2 formation. CPR concentrations were as follows: 50 nM (●), 100 nM (○), 200 nM (■), 400 nM (□), 800 nM (▼), 1200 nM (△).