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. Author manuscript; available in PMC: 2009 Mar 20.
Published in final edited form as: Brain Res. 2008 Jan 26;1200C:27–38. doi: 10.1016/j.brainres.2008.01.038

Fig. 3. Effect of melatonin on depression-like behavior.

Fig. 3

A: When examined on postoperative day 7, the immobility time in the forced swimming test (FST) in WKY rats was significantly improved by melatonin (MT, 4 µg, once daily × 7 days) administered into the ACC contralateral to CCI. The melatonin effect was blocked by the broad MT receptor antagonist luzindole [10 µg but not 5 µg (L10, L5)] injected into the same ACC at 10 min before melatonin (4 µg). *P<0.05, as compared with the sham-vehicle (V) group; ++ P<0.01, as compared with the CCI-vehicle group; ## P<0.01, as compared with the CCI-MT group. B. The same melatonin (MT) treatment also improved the immobility time in the horizontal suspension test (HST) in WKY rat on day 7 after CCI. *P#0.05, as compared with sham and CCI-MT groups.