Table 1. Sensitivity of clones to doxorubicin and mitoxantrone.
| Parental MCF-7 | 14 nM clone 1 | 14 nM clone 2 | 14 nM clone 6 | 14 nM clone 11 | 14 nM clone 13 | 14 nM clone 16 | 21 nM clone 1 | |
|---|---|---|---|---|---|---|---|---|
| Doxorubicin | ||||||||
| IC50 (nM) | 89.7 | 111.1 | 118.9 | 173.7 | 284.7 | 264.4 | 260.7 | 323.0 |
| s.d. | 28.2 | 27.3 | 50.8 | 46.3 | 56.7 | 65.6 | 51.8 | 63.4 |
| Mitoxantrone | ||||||||
| IC50 (nM) | 15.6 | 33.1 | 15.4 | 319.1 | 158.6 | 220.1 | 172.4 | 1407.0 |
| s.d. | 6.0 | 6.1 | 7.5 | 114.8 | 11.4 | 56.2 | 40.3 | 310.2 |
IC50 values are given in nM and are mean±s.d. The IC50 values were calculated from dose–response curves obtained from at least three independent experiments. Cytotoxicity assays were performed as described in Materials and Methods.