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. Author manuscript; available in PMC: 2009 Apr 1.
Published in final edited form as: Pharmacol Biochem Behav. 2007 Dec 15;89(2):188–199. doi: 10.1016/j.pbb.2007.12.009

Fig. 2. Periadolescent males, but not females, are more sensitive than their adult counterparts to morphine-induced antinociception as measured using the hot plate test.

Fig. 2

Hot plate latencies were measured in 20 min intervals after administration of either saline (SAL) or cumulative doses of morphine (A: males; C: females). Hot plate latencies continued to be recorded (20–60 min intervals) following the last injection of morphine (B: males; D: females). Data are presented as a percentage of the maximum possible effect (% MPE), as defined in the text. Each point represents the mean ± S.E.M. (n=8/group). #Indicates a significant difference between periadolescents and adults, P<0.05. @Indicates significant differences between genders of same age group, P<0.05.