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. Author manuscript; available in PMC: 2009 Apr 1.
Published in final edited form as: Pharmacol Biochem Behav. 2007 Dec 15;89(2):188–199. doi: 10.1016/j.pbb.2007.12.009

Fig. 6. Morphine exposure differentially impacts subsequent morphine-induced vertical activity in male rats but not female rats.

Fig. 6

Male (A, B) and female (C, D) rats were treated with one of four injection regimens as detailed in Fig. 6. Five weeks later, vertical activity was assessed (2 h) immediately following the administration of saline or increasing doses of morphine. Each data point represents the mean ± S.E.M. (n=6–8). *Indicates a significant difference from S-S-S-S-S treated cohorts; mixed three-factor ANOVA, Newman-Keuls post hoc, P<0.05.