Table 5.
Genetic interaction between NK genotype receptor and HLA- DR*1201.
| SC | CV | |||
|---|---|---|---|---|
| N= 39 | N=121 | |||
| n (%) | n (%) | OR (CI) | p value | |
| KIR 2DL3/2DL3 (−) + HLA-DRB1*1201 (−) | 16 (41.0) | 72 (59.5) | 1 | - |
| KIR 2DL3/2DL3 + HLA-DRB1*1201 (−) | 17 (43.6) | 45 (37.2) | 1.7 (0.72–3.98) | 0.17 |
| KIR 2DL3/2DL3 (−) + HLA-DRB1*1201 | 2 (5.1) | 2 (1.6) | 4.5 (0.30–64.9) | 0.17 |
| KIR 2DL3/2DL3 + HLA-DRB1*1201 | 4 (10.2) | 1 (0.8) | 18.0 (1.57–898.0) | 0.007 |
| KIR 2DL3 (one or two copies) (−) + HLA- DRB1*1201 (−) | 7 (17.9) | 36 (29.7) | 1 | - |
| KIR 2DL3 (one or two copies) + HLA- DRB1*1201 (−) | 26 (66.7) | 82 (67.8) | 1.63 (0.61–4.85) | 0.29 |
| 2DL3 one or two copies (−) + HLA- DRB1*1201 | 0 | 1 (0.8) | ND | 0.84 |
| 2DL3 one or two copies + HLA- DRB1*1201 | 6 (15.4) | 2 (1.6) | 15.4 (2.04–172.5) | 0.002 |
KIR inhibitory genotypes: 2DL3/2DL3: (2DL3 (+), 2DL2 (−), 2DS2 (−); 2DL3/2DL3 (−): 2DL2 (+), 2DL3 (−) 2DS2 (+) SC: Spontaneous clearance,