Figure-3.

A simplified schematic representation of the various cell cycle phases, and the different cyclins and their kinases that control progression through the cycle. At the core of this control is the cyclin dependent kinase (Cdk) family of serine/threonine kinases, which regulate cell cycle progression through phosphorylation of proteins that function at specific phase of the cell cycle. Different Cdks act at different phases of the cell cycle and their activity is dependent on association with a member of the cyclin family of regulatory sub-units. Different dietary agents, such as EGCG, GSPs, silymarin, apigenin, resveratrol, genistein and curcumin act at different checkpoints as illustrated in the Figure. Some of them act on multiple checkpoints or targets. The arrows indicate activation and blocked signs indicate inhibitory effects.