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. Author manuscript; available in PMC: 2008 May 19.
Published in final edited form as: Neuron. 2005 Sep 1;47(5):681–694. doi: 10.1016/j.neuron.2005.08.017

Figure 8. Schematic Summary of Abnormalities in Nerves with Altered NRG1 Type III Levels.

Figure 8

Alterations in axon ensheathment and myelination as a function of NRG1 type III levels are illustrated based on in vivo and in vitro analysis. In wt mice, unmyelinated axons in the PNS are segregated into separate pockets of Remak bundles and myelinated axons are fully wrapped. In NRG1 type III+/− mice, a greater proportion of axons remain unmyelinated and are frequently fasciculated together in Remak bundles, sometimes with distorted cross-sectional profiles; myelinated axons have thinner sheaths. In the absence of NRG1type III, Schwann cells fail to ensheath axons and even large axons remain unsegregated and unmyelinated.