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. 2008 Jun 4;3(6):e2368. doi: 10.1371/journal.pone.0002368

Figure 3. Immune responses against pneumococcal capsular polysaccharides.

Figure 3

a) IgG responses at day 30 to PS3 in mice immunized once with liposomes incorporating PS3 (10 µg), PS14 (10 µg) and CD40mAb (10 µg) (solid lines), or PS14, PS3 and control mAb (all 10 µg) (broken lines). CD40mAb/liposome immunised group produced significantly higher titres against PS3 than the control mAb liposome group (IgG GMTs 105 and 11 respectively) p = 0.007, Student's t test. b) IgG responses at day 30 to PS3 in mice immunized once with liposomes incorporating PS3 (10 µg), PS14 (10 µg) and either CD40mAb (10 µg) (solid lines), or control mAb (all 10 µg) (broken lines) incorporated into separate liposomes. Geometric mean titers against PS3 were 11.5 for the control mAb group, and 38 for the CD40mAb group. c) IgG responses 14 days post-boost against PS14 in mice immunized as above. Only two of the 5 mice from the CD40mAb group, and none of the mice from the control mAb group, produced a detectable IgG response against PS14. Overall there was no significant enhancement of responses.