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. 2008 Jun 4;3(6):e2368. doi: 10.1371/journal.pone.0002368

Figure 4. Effect of liposomal entrapment of CD40mAb on toxicity.

Figure 4

Increase in spleen size following immunization with liposomally entrapped or free CD40 antibodies. The equivalents of 2, 10 and 50 µg of antibody was injected intraperitoneally into BALB/c mice (3 per group). Spleen weights are shown, the four right hand groups (cont) were injected with isotype control antibody, the rest with CD40 antibody, either free in PBS (free), or encapsulated in liposomes (lipo). Differences in spleen weights were assessed versus 10 µg of free control antibody. Only two groups had significantly enhanced spleen weights (p<0.05, *, ANOVA with Dunnett's correction for multiple comparisons).