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. 2007 Oct 3;27(40):10695–10702. doi: 10.1523/JNEUROSCI.2178-07.2007

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Copyright © 2007 Society for Neuroscience 0270-6474/07/2710695-08$15.00/0

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Figure 3. — Unsupervised clustering of microarray data show anti-IL-6 treatment rescues transcriptome changes in MIA offspring. Sixty-one genes show significant (p < 0.01) expression differences between the adult offspring of poly(I:C)-treated and saline-injected mice. Two-dimensional, unsupervised clustering of these genes (x-axis genes, y-axis samples) reveals control (Sal; blue bars), poly(I:C) (pIC; red bars), and poly(I:C) plus anti-IL-6 (pIC+aIL6; purple bars) animals cluster according to treatment, with only one pIC+aIL6 outlier. Significantly, the pIC+aIL6 animals cluster with saline-injected controls, rather than with pIC offspring. Each column represents expression values from a single animal. Genes are annotated by Affymetrix probe set/Unigene identifiers. Color intensity represents the magnitude of the gene expression change compared with the overall average intensity (green, decreased; red, increased; black, unchanged).