Fig. 1.
Ca2+ responses induced by urotensin-II (U-II) in human aortic endothelial cells. Addition of U-II (1, 10, 100 nM) to perfusing saline increased [Ca2+]i by an additional 72 ± 4 (n=16), 168 ±5 (n=12) and 463 ± 8.4 nM (n=15), respectively. In a Ca2+-free saline, U-II (100 nM) induced a transitory increase in [Ca2+]i by 348 ± 6.4 nM (n=9). The asterisk denotes statistically significant difference as compared to control.