Table.
Multivariate Adjusted Relative Risks (95% CI) of Parkinson’s Disease According to Categories of Baseline Recreational Physical Activity in the Cancer Prevention Study II Nutrition Cohort (1992–2001), Primary Analysesa
| Men and women
|
Men
|
Women
|
||||
|---|---|---|---|---|---|---|
| Cases/PY | RR (95%CI) | Cases/PY | RR (95%CI) | Cases/PY | RR (95%CI) | |
| Total activity (light and moderate to vigorous activity combined) | ||||||
| Zero activity | 38/117,685 | 1.0 (ref) | 28/59,765 | 1.0 (ref) | 10/57,920 | 1.0 (ref) |
| 3.5 MET-h/wk (men and women) | 112/333,679 | 1.1 (0.7, 1.6) | 72/136,152 | 1.0 (0.7, 1.6) | 40/197,527 | 1.2 (0.6, 2.5) |
| 4.0–13.5 MET-h/wk (men); 4.0–8.5 MET-h/wk (women) | 77/195,447 | 1.2 (0.6, 2.2) | 45/92,955 | 0.9 (0.6, 1.5) | 32/102,492 | 1.8 (0.8, 3.7) |
| 14.0–22.5 MET-h/wk (men); 9.0–18.0 MET-h/wk (women) | 104/284,101 | 1.0 (0.7, 1.5) | 67/124,020 | 0.9 (0.6, 1.5) | 37/160,081 | 1.3 (0.6, 2.6) |
| ≥ 23 MET-h/wk (men); = 18.5 MET-h/wk (women) | 78/264,171 | 0.8 (0.6, 1.2) | 52/119,218 | 0.8 (0.5, 1.2) | 26/144,954 | 1.0 (0.5, 2.2) |
| P for trend | 0.07 | 0.09 | 0.46 | |||
| Moderate to vigorous activity (with or without light activity) | ||||||
| Zero activity or light activity only | 254/723,015 | 1.0 (ref) | 170/324,256 | 1.0 (ref) | 84/398,759 | 1.0 (ref) |
| 4 MET-h/wk (men and women) | 54/142,213 | 1.1 (0.7, 1.6) | 30/61,104 | 0.9 (0.6, 1.3) | 24/81,108 | 1.3 (0.8, 2.1) |
| 4.5–6.0 MET-h/wk (men); 4.5 MET-h/wk (women) | 37/85,572 | 1.2 (0.9, 1.7) | 23/32,091 | 1.2 (0.8, 1.9) | 14/53,481 | 1.2 (0.7, 2.1) |
| 6.5–15.5 MET-h/wk (men); 5.0–11.0 MET-h/wk (women) | 33/120,826 | 0.8 (0.3, 1.8) | 17/59,052 | 0.5 (0.3, 0.8) | 16/61,774 | 1.2 (0.7, 2.0) |
| ≥ 16 MET-h/wk (men); = 11.5 MET-h/wk (women) | 31/123,458 | 0.6 (0.4, 1.0) | 24/55,607 | 0.7 (0.5, 1.1) | 7/67,851 | 0.4 (0.2, 1.0) |
| P for trend | 0.02 | 0.08 | 0.07 | |||
Results for men and women were pooled using random effects models. Light activity included walking and dancing; moderate to vigorous activity included jogging/running, lap swimming, tennis or racquetball, bicycling/stationary bike, and aerobics/calisthenics. Models were adjusted for age, pack years of smoking, years since quitting smoking, alcohol intake, caffeinated coffee intake, total caloric intake, dairy intake, body mass index, pesticide exposure, ibuprofen use, and level of education.
PY = person years; RR = relative risk; CI = confidence interval; MET = metabolic equivalent task.