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. Author manuscript; available in PMC: 2009 Apr 30.
Published in final edited form as: J Neurosci Methods. 2007 Oct 24;169(2):282–289. doi: 10.1016/j.jneumeth.2007.10.009

Figure 7. Whole-cell patch-clamp recordings demonstrate the effects of time step (Ts) and latency under real-world conditions.

Figure 7

In measurements from CA1 pyramidal cells, we recorded action potentials under control conditions (A) and with virtualized Na+ channels (B). We also introduced long time steps (C) and latencies (D). Effects in experiments were qualitatively similar to those in simulations, but experimental data were more sensitive to inaccuracies than were simulated data from previous figures.