Table 2.
SAGE tags significantly decreased in metastatic melanoma cells (MMC) compared to normal melanocytes (NM)
| GATC preceded Tag | Count | p value | GenBank match [accession number] | |
| NM | MMC | |||
| Translation, ribosomal structure and biogenesis | ||||
| GTCGTTCTGG | 52 | 29 | 0.015 | Ss eukaryotic translation elongation factor 1 alpha 1 [NM_001097418] |
| GACTTTGACA | 6 | 0 | 0.016 | Ss cDNA [BX676185] homolog to Hs eukaryotic translation initiation factor 3 subunit k, eIF3k [AY245432] |
| TGTCAAAAAA | 22 | 9 | 0.025 | Ss ribosomal protein L29, RPL29 [NM_213950] |
| TCTGGAAAGA | 24 | 11 | 0.027 | Ss cDNA [BX675247] homolog to Hs ribosomal protein S2, RPS2 [BC019021] |
| TCTGACTACC | 5 | 0 | 0.031 | Ss cDNA [BX922533] homolog to Hs mitochondrial ribosomal protein L40, MRPL40 [NM_003776] |
| AGAAAGCTGT | 9 | 2 | 0.042 | Ss ribosomal protein L6, RPL6 [NM_001044542] |
| AGCGTTCAGC | 39 | 23 | 0.049 | Ss 40S ribosomal protein S16, RPS16 [AY550068] |
| Transcription | ||||
| AGGGGAAATG | 11 | 3 | 0.041 | Ss cDNA [BX665090] homolog to Hs small nuclear ribonucleoprotein D3, [BC034447] |
| Secondary metabolites biosynthesis | ||||
| ACCCTGGCTG | 90 | 46 | 0.000 | Ss cDNA [BX 920958] homolog to Equus caballus melanocyte protein 17 precursor, PMEL17 [AF076780] |
| CACTGCTCAA | 16 | 6 | 0.038 | Ss glycoprotein [transmembrane] nmb GPNMB [NM_001098584] |
| Energy production and conversion | ||||
| CTAAAAAAAA | 18 | 5 | 0.006 | Ss mitochondrial COX III [AJ953126] |
| TCAGAAGAGA | 15 | 4 | 0.012 | Ss cDNA [CN155299] homolog to Hs ATP synthase, H+ transporting, mitochondrial F1 complex, a subunit, isoform 1, ATP5A1 [BC008028] |
| TCACCTGGGG | 9 | 2 | 0.042 | Ss cDNA [CB477260] homolog to Hs ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit, ATPE [BC003671] |
| Cell division | ||||
| CCCAACAATG | 5 | 0 | 0.031 | Ss beta 5-tubulin, [NM_001044612] |
| Posttranslational modification, protein turnover | ||||
| TCTAAAGCGG | 7 | 0 | 0.009 | Ss cDNA [BX672659] homolog to Hs glucose regulated protein 58 KD, GRP58 [NM_005313] |
| AGTGGCTTTG | 7 | 1 | 0.043 | Ss cDNA [CJ007805] homolog to Hs proteasome [prosome, macropain] subunit, beta type, 4, HsN3 [BC008314] |
| AGGGAATGGA | 5 | 0 | 0.031 | Ss cathepsin B, CTSB [NM_001097458] |
| General prediction only | ||||
| AGCATCCAGA | 5 | 0 | 0.031 | Ss cDNA [BX925627] homolog to Hs nuclear distribution gene C homolog, NUDC [NM_006600] |
| CAGAGCTGCC | 5 | 0 | 0.031 | Ss cDNA [CK459123] homolog to Hs SET binding factor 1, SBF1 [NM_002972] |
| CTAGACGACT | 7 | 1 | 0.043 | Ss cDNA [BX676609] homolog to Hs arginine-rich, mutated in early stage tumors, ARMET [NM_006010] |
| Function unknown | ||||
| AGATGGCCAG | 7 | 0 | 0.009 | No reliable matches |
| AGCTTAAGCA | 6 | 0 | 0.016 | Ss cDNA [BX922388] |
| ATGTGCCTGG | 6 | 0 | 0.016 | Ss cDNA [BX674457] |
| AGACTTTTAA | 6 | 0 | 0.016 | Ss cDNA [EW337487] |
| TATGGGGGTC | 6 | 0 | 0.016 | Ss cDNA [EW673617] |
| AGCCTGGACC | 5 | 0 | 0.031 | No reliable matches |
| CCTAGCCTGG | 5 | 0 | 0.031 | Ss cDNA [DY430777] |
| TGGCATGGCT | 5 | 0 | 0.031 | Ss cDNA [BX920198] |
| AGCTGTTCTA | 11 | 3 | 0.041 | Ss cDNA [BX670542] |
| CACCCGCAAT | 9 | 2 | 0.042 | No reliable matches |
| AGTCCCTGTG | 7 | 1 | 0.043 | No reliable matches |
| TTTGCAAGGG | 7 | 1 | 0.043 | Ss cDNA [CJ006347] |