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. Author manuscript; available in PMC: 2009 May 1.

Published in final edited form as: Biomaterials. 2008 Mar 3;29(15):2336–2347. doi: 10.1016/j.biomaterials.2008.01.033

Representative images of microvasculature at 7 days post-surgery, IHC double stained for α-SMA (brown) and vWF (red), 400×. The contralateral ear (a) exhibited mature vasculature (bin 3 microvessels indicated by long arrows). There were no hyperfused capillary networks in these ears and, in general, vascular densities were relatively low. Time related variations in vasculature were minimal to non-existent. HA:Hp-VEGF treated tissue exhibited the least mature vasculature at 7 days post surgery (b). All hyperfused vessels in this field (short arrows) were characterized as bin 1, due to the lack of both clearly defined endothelial borders as well as pericyte association. HA:Hp-VEGF+KGF treated tissue (c) exhibited, by far, the most mature vasculature of all 7 day experimental cases (all vessels belonging to bin 3 are indicated by long arrows).

Representative images of microvasculature at 7 days post-surgery, IHC double stained for α-SMA (brown) and vWF (red), 400×. The contralateral ear (a) exhibited mature vasculature (bin 3 microvessels indicated by long arrows). There were no hyperfused capillary networks in these ears and, in general, vascular densities were relatively low. Time related variations in vasculature were minimal to non-existent. HA:Hp-VEGF treated tissue exhibited the least mature vasculature at 7 days post surgery (b). All hyperfused vessels in this field (short arrows) were characterized as bin 1, due to the lack of both clearly defined endothelial borders as well as pericyte association. HA:Hp-VEGF+KGF treated tissue (c) exhibited, by far, the most mature vasculature of all 7 day experimental cases (all vessels belonging to bin 3 are indicated by long arrows).