Figure 2.

Median neutrophil nadirs by treatment course, dose, and granulocyte-colony stimulating factor (G-CSF). After the first course, patients may have received G-CSF or reduced doses of topotecan; some patients may have discontinued topotecan because of myelosuppression. Copyright © 2005. Reprinted with permission from Armstrong DK, Spriggs D, Levin J, et al. 2005. Hematologic safety and tolerability of topotecan in recurrent ovarian cancer and small cell lung cancer: an integrated analysis. Oncologist, 10:686–94