Table 1.
RNA-binding ligands
| ID# | Structures | Frequency | Color | KD, nM | KREL |
|---|---|---|---|---|---|
| 1 | NH2-(l)Lys-(d)Lys-(l)Asn-OH | 2 | Red | 420 ± 44 | 1.73 |
| 2 | NH2-(l)Lys-(d)Lys-(d)Asn-OH | 1 | Pink | 4,173 ± 208 | 0.17 |
| 3 | NH2-(l)Lys-(l)Lys-(l)Asn-OH | 2 | Pink | 3,224 ± 183 | 0.23 |
| 4 | NH2-(l)Arg-(d)Lys-(l)Ala-OH | 1 | Pink | 2,640 ± 219 | 0.28 |
| 5 | NH2-(l)Arg-(d)Lys-(d)Val-OH | 1 | Pink | 10,434 ± 594 | 0.07 |
| 6 | NH2-(l)Arg-(d)Lys-(l)Arg-OH | 1 | Pink | 878 ± 80 | 0.83 |
| 7 | NH2-(d)Thr-(d)Lys-(l)Asn-OH | 1 | Pink | 564 ± 80 | 1.29 |
| 8 | NH2-(d)Thr-(d)Lys-(l)Phe-OH | 1 | Pink | 2,087 ± 244 | 0.35 |
KD values were determined from four independent experiments. KREL = KD of a basic Tat peptide (727 ± 74 nM)/KD of inhibitor. The bead library peptides all were N-acetylated. Peptides used for in vitro and in vivo experiments were not N-acetylated and contained free amino termini.