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Summary of binding data of sCD4, CD4M3, and its mutants to recombinant gp120s
| Competitor | IC50
|
|||||
|---|---|---|---|---|---|---|
| gp120LAI | gp120IIIB | gp120MN | gp120BaL | gp120JR-FL | gp120W91D | |
| sCD4, nM | 4.0 | 2.0 | 4.5 | 5.0 | 5.0 | 7.0 |
| CD4M3, μM | 40 | 100 | 150 | 350 | 200 | 20 |
| CD4M8, μM | 2.3 | — | — | — | — | — |
| CD4M9, μM | 0.4 | 1.0 | 0.4 | 1.0 | 1.0 | 0.1 |
IC50 for each molecule was obtained in competetive ELISA. Data are means of triplicate assays; SDs were within 15% of the mean.
