Figure 1.

Effects of TFIIS siRNA on Cell Proliferation. MCF7 and MCF10A cell lines were subjected to siRNA directed at TFIIS as listed in Table 1, scrambled siRNA (S-siRNA) or Eg5 and MTS values determined 72 hours after transfection. Cell proliferation represents the fraction of viable cells compared to cells transfected with vehicle alone (1 = 100% viable cells when treated with vehicle alone). Standard error of the mean is indicated as bars in the figure. Caspase-3/7 activity is also depicted and normalized to cell number represented by MTS values. Total activity was then normalized to activity in cells treated with vehicle alone.