Figure 6.—

The Yta7 protein localizes to histone gene loci. ChIP-chip analysis of Yta7-Myc from asynchronous cells using 50-bp resolution tiled arrays (NimbleGen Systems). (A) Yta7 associated DNA occupancy is plotted as a function of relative coordinates on an average gene flanked with intergenic regions. (B) Shown is Yta7-Myc binding at the four histone loci: HTB1 and HTA1, HHF1 and HHT1, HHT2 and HHF2, and HTA2 and HTB2. The log₂ intensity ratio of immunoprecipitated to control DNA is plotted as a function of genomic position. Error bars are the standard deviation of triplicate array analyses.