TABLE 1.

Candidate genes within the congenic region on chromosome 11

Gene symbol	Gene name	Location (bp)	Protein function	Expression	Mouse model
Srebf1	Sterol regulatory element binding factor 1	60015284	Transcriptional activator, cholesterol synthesis	Testis, germ cells	Knockout viable, disrupted cholesterol synthesis
Ncor1	Nuclear receptor corepressor 1	62132885	Negative regulation of transcription	Ovary, vagina	Knockout embryonic/perinatal lethal
Trp53	Transformation related protein 53	69396176	Cell cycle and apoptosis	Germ cells, ovary, testis, uterus	Knockout displays early-onset tumor incidence, disrupted vasculature
Shbg	Sex hormone binding globulin	69431011	Lipid binding, transport	Sertoli cells
Sox15	SRY-box containing gene 15	69471232	Regulation of transcription	Testicular cords, ovary, urogenital system	Knockout viable, muscle abnormalities; no sex determination phenotype observed
Dvl2	Dishevelled 2, dsh homolog (Drosophila)	69816821	Wnt signaling	Ovary, testis	Knockout incompletely perinatal lethal, surviving animals predominantly female
Foxn1	Forkhead box N1	78174483	Transcriptional regulator involved in development	Testis	Targeted and natural mutants show keratinocyte and immune abnormalities
Nle1	Notchless homolog 1 (Drosophila)	82716966	Nuclear localization	Testis, ovary	Knockout lethal prior to somite formation
Lhx1	LIM homeobox protein 1	84335666	Regulation of transcription	Urogenital sytem	Knockout embryonic lethal lacking kidneys and gonads
Tbx2	T-box 2	85649273	Regulation of transcription	Urogenital ridge	Knockout embryonic lethal with cardiac and vascular abnormalities
Tbx4	T-box 4	85713027	Regulation of transcription	Oocyte	Knockout embryonic lethal, impaired allantois growth, lack of hindlimb buds

Genes were selected on the basis of a combination of location within the congenic region on chromosome 11, gonadal expression, and function during development. Knockout mouse models and their phenotypes are listed when available.