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. 2008 May;179(1):637–650. doi: 10.1534/genetics.107.082370

TABLE 4.

Type I error rates of the association test based on statistic Tgene at the 0.05 nominal level

LD based
n MS program PD = 0.1 PD = 0.3 PD = 0.5
100 0.081 (0.025) 0.046 (0.022) 0.061 (0.025) 0.043 (0.030)
200 0.073 (0.038) 0.066 (0.015) 0.047 (0.025) 0.046 (0.025)
400 0.052 (0.027) 0.060 (0.030) 0.046 (0.027) 0.045 (0.032)

Data are simulated with the MS program and the LD-based approach. The type I error for the single SNP analysis is given in parentheses. PD refers to disease allele frequency.