TABLE 5.
Power of the association test based on statistic Tgene assuming one disease locus in a tested gene under different sample sizes and different simulation schemes. The power for the single SNP analysis is given in parenthesis
| MS program
|
LD based (r2 = 0.9)
|
||||
|---|---|---|---|---|---|
| Disease model | (prev, GRR) | n = 200 | n = 400 | n = 200 | n = 400 |
| Additive | (0.1, 1.4) | 0.370 (0.255) | 0.588 (0.607) | 0.438 (0.305) | 0.766 (0.651) |
| (0.1, 1.6) | 0.602 (0.555) | 0.897 (0.902) | 0.681 (0.577) | 0.943 (0.934) | |
| Multiplicative | (0.1, 1.4) | 0.402 (0.367) | 0.735 (0.752) | 0.521 (0.384) | 0.808 (0.751) |
| (0.1, 1.6) | 0.751 (0.687) | 0.960 (0.953) | 0.812 (0.743) | 0.970 (0.974) | |
prev, population prevalence; GRR, genotype relative risk. For both simulation schemes, we set the third SNP as the disease locus. The disease allele frequency for the LD-based simulation is set as PD = 0.3. The significance level is 0.05.