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Tic62 is an extended short-chain dehydrogenase. The conserved domains of full-length Tic62 are modeled with an N-terminal NAD-binding domain, which is classified within the “extended” class of short-chain dehydrogenases (red), and a C-terminal FNR-binding domain (green). Homologs from nonvascular genomes encode only the NAD-binding domain. The signature motif of extended SDR proteins is shown (G-x-x-G-x-x-G, black dots).
