Table 1. Genes differentially expressed in the presence of ciprofloxacin.
Gene ID and Functional Category | P-Value | Q-Value | n-Fold change | ||
Microarray | qRT-PCR | ||||
Cell membrane | |||||
Cj0205 | uppP, undecaprenyl-diphosphatase | 0.0135 | 0.130143 | 1.59 | 6.1 |
Cj0735 | putative periplasmic protein | 0.0186 | 0.14811 | 1.70 | NT* |
Cj0824 | uppS, undecaprenyl diphosphate synthase | 0.0099 | 0.120356 | 1.52 | 2.1 |
Cj1351 | pldA, phospholipase A | 0.0046 | 0.094812 | 2.02 | 2 |
Cj0033 | putative integral membrane protein | 0.0033 | 0.086471 | −1.52 | NT |
Cj0179 | exbB1, biopolymer transport protein | 0.0412 | 0.217646 | −1.88 | NT |
Cj0486 | putative sugar transporter | 0.0043 | 0.091967 | −1.57 | NT |
Cj0553 | putative integral membrane protein | 0.0106 | 0.121714 | −1.59 | NT |
Cj0834c | ankyrin repeat-containing possible periplasmic protein | 0.0089 | 0.110719 | −1.51 | NT |
Cj1013c | putative cytochrome C biogenesis protein | 0.0058 | 0.096095 | −1.52 | NT |
Cj1662 | putative integral membrane protein | 0.0055 | 0.096095 | −1.68 | NT |
Cj1663 | putative ABC transport system ATP-binding protein | 0.0002 | 0.067622 | −1.75 | NT |
DNA replication, recombination and repair | |||||
Cj1085c | mfd, transcription-repair coupling factor | 0.0029 | 0.082832 | 1.57 | 2.2 |
Cj0718 | dnaE, DNA polymerase III, alpha chain | 4.07E-05 | 0.052459 | −1.62 | −1.98 |
Cellular process and energy metabolism | |||||
Cj0041 | putative flagellar hook-length control protein | 0.0357 | 0.204764 | 1.93 | NT |
Cj0065c | folk, putative 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase | 0.0117 | 0.129371 | 1.54 | NT |
Cj1030c | lepA, GTP-binding protein homolog | 0.0057 | 0.210454 | 1.54 | NT |
Cj1280c | putative ribosomal pseudouridine synthase | 0.0252 | 0.170564 | 1.50 | NT |
Cj0009 | gltd, glutamate synthase (NADPH) small subunit | 0.0007 | 0.067622 | −1.74 | NT |
Cj0123c | putative tRNA-dihydrouridine synthase | 0.0020 | 0.076881 | −1.87 | −2.1 |
Cj0227 | argD, acetylornithine aminotransferase | 0.0208 | 0.151677 | −1.69 | NT |
Cj0283c | cheW, chemotaxis protein | 0.0125 | 0.130143 | −1.52 | NT |
Cj0415 | putative GMC oxidoreductase subunit | 0.0191 | 0.148174 | −1.53 | NT |
Cj0490- | ald, putative aldehyde dehydrogenase C-terminus | 0.0013 | 0.076653 | −1.80 | NT |
Cj0537 | oorb, OORB subunit of 2-oxoglutarate:acceptor oxidoreductase | 0.0024 | 0.076881 | −1.67 | −2.23 |
Cj0734c | hisJ, histidine-binding protein precursor | 0.0404 | 0.214389 | −1.59 | NT |
Cj0764c | speA, biosynthetic arginine decarboxylase | 0.0116 | 0.129371 | −1.97 | −1.96 |
Cj0767c | kdtB,3-deoxy-D-manno-octulosonic-acid transferase | 0.0370 | 0.207688 | −1.58 | NT |
Cj1264c | hydD, putative hydrogenase maturation protease | 0.0009 | 0.067622 | −2.13 | −6.7 |
Cj1265c | hydC, Ni/Fe-hydrogenase B-type cytochrome subunit | 0.0016 | 0.076881 | −2.12 | NT |
Cj1266c | hydB, Ni/Fe-hydrogenase large subunit | 0.0032 | 0.086244 | −1.56 | NT |
Cj1364c | fumC, fumarate hydratase | 0.0255 | 0.171473 | −1.52 | NT |
Cj1476c | pyruvate-flavodoxin oxidoreductase | 0.0133 | 0.130143 | −1.55 | NT |
Cj1566c | nuoN, NADH dehydrogenase I chain N | 0.0039 | 0.088549 | −2.03 | −2.71 |
Cj1567c | nuoM, NADH dehydrogenase I chain M | 0.0055 | 0.096095 | −1.60 | NT |
Cj1624c | sdaA, L-serine dehydratase | 0.0046 | 0.094812 | −1.58 | NT |
Cj1682c | gltA, citrate synthase | 0.0167 | 0.142007 | −1.54 | NT |
Cj1688c | secY, preprotein translocase subunit | 0.0021 | 0.076881 | −1.63 | −2.15 |
Cj1717c | leuC, 3-isopropylmalate dehydratase large subunit | 0.0018 | 0.076881 | −1.61 | NT |
Unknown function | |||||
Cj0163c | hypothetical protein | 0.0204 | 0.151393 | 1.60 | NT |
Cj0814 | hypothetical protein | 0.0002 | 0.067622 | 1.99 | NT |
Cj0959c | hypothetical protein | 0.0233 | 0.160562 | 1.50 | NT |
Cj1025c | hypothetical protein | 0.0389 | 0.210454 | 1.54 | NT |
Cj0125c | hypothetical protein Cj0125c | 0.0031 | 0.084482 | −1.53 | NT |
Cj0554 | hypothetical protein | 0.0083 | 0.107589 | −1.71 | NT |
*: NT: Not tested.