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. Author manuscript; available in PMC: 2008 Jul 15.
Published in final edited form as: Cancer Res. 2007 Jul 15;67(14):6637–6646. doi: 10.1158/0008-5472.CAN-07-0751

Figure 4. Silencing of uPA expression inhibited tumor growth in an orthotopic mouse prostate tumor model.

Figure 4

(A) Photon counts of orthotopic prostate tumors on days 10, 20 and 40 (left). Nude mice carrying an orthotopic prostate tumor, established from either mock or siMM-transfected PC3-luc cells, showed substantial bioluminescence signal as indicated by photon counts on day 40. In contrast, the orthotopic prostate tumors developed from PC3-luc cells transfected with siuPA showed significantly low bioluminescence signal (right).(B) Comparison of dissected prostate tumors in (A) from mice 40 days after cell implantation (p<0.01).(C) We excised and photographed prostate tumors in (A) from mice 40 days after cell implantation.(D) RNA samples extracted from PC3-luc prostate tumors (6 animals per group) were analyzed using RT-PCR for uPA expression levels. The siuPA group showed the most prominent and specific knockdown of uPA. GAPDH was used as a control and remained unchanged.