Skip to main content
. Author manuscript; available in PMC: 2008 Jul 15.
Published in final edited form as: Cancer Res. 2007 Jul 15;67(14):6637–6646. doi: 10.1158/0008-5472.CAN-07-0751

Figure 5. Inhibition of metastatic tumor growth in lungs by promoter-directed uPA siRNA.

Figure 5

(A) Bioluminescence signal in the lung, representative of lung metastasis, was recorded for each mouse. Lung images from different mice (top). Lung metastasis signals were analyzed by photon counts (bottom, p<0.01). We observed significant inhibition of lung metastasis in PC3-luc cells transfected with siuPA relative to the control groups.(B) Scatter plot of the lung surface metastasis counts of mice implanted with control and uPA knockdown cells.(C) Effect of uPA silencing on the metastatic potential of PC3-luc cells.(D) Tumors metastasized to lung in (A) from mice were examined for uPA expression by RT-PCR. GAPDH was used as a control and remained unchanged.