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(A) A long-range tertiary interaction between tandem sheared purine–purine pairs and consecutive G-C pairs observed in the structure of the 23S rRNA (Ban et al. 2000). Dashed line denotes a hydrogen bond between H1 of A and 2′-OH of C. (B) A schematic of tertiary interaction involving one of sheared A·A pairs in the internal loop of D3 and the Watson–Crick pair G3-C117 in D1. (C) A schematic of the same interaction upon a mutation of an A·A pair to a C·A.
