Table 2.
Activated lin-12/Notch mutant suppresses the lethality and sterility phenotypes of let-7 mutations
| Genotype | No. of progeny a | Fertile wormsb |
|---|---|---|
| N2 (wild-type) | 280±12 | 100 % |
| lin-12(n137n460gf) | 21±2 | 100 % |
| let-7(n2853lf) | 0 | 2–5 % |
| lin-12(n137n460gf), let-7(n2853lf) | 23±3 | 100 % |
| let-7(nm112null), unc-3(e151) | 0 | 2–5 % |
| lin-12(n137n460gf), let-7(nm112), unc-3(e151) | 32±3 | 100 % |
|
| ||
| lin-41(ma104lf) | 30c | 100 %c |
| lin-41(ma104lf), let-7(nm112), unc-3(e151) | 19 c | 95 % c |
a
Average number of live progeny from ten adults worms at 25°C.
b
Percent of worms (n >100) with fertile eggs scored at 25°C.
c
From Slack et al. Molecular cell, 5 659–669, 2000.