. Author manuscript; available in PMC: 2008 Jul 1.

Published in final edited form as: Am J Obstet Gynecol. 2007 Nov 5;198(1):37.e1–37.e8. doi: 10.1016/j.ajog.2007.05.033

Table 2.

Association between quintiles of lycopene^* intake and incidence of uterine leiomyoma, Nurses’ Health Study II 1991–2001

	Lycopene intake (quintiles)^*
	Q1	Q2	Q3	Q4	Q5	p_trend
Baseline
Person years	137450	140286	138657	137712	138098
Cases	1276	1215	1277	1307	1227
Age adjusted HR, 95% CI	1.00	0.92 (0.85, 1.00)	0.96 (0.89, 1.04)	0.99 (0.91, 1.07)	0.92 (0.85, 1.00)	0.19
Multivariate adjusted HR^**, 95% CI	1.00	0.95 (0.88, 1.03)	0.98 (0.91, 1.06)	1.00 (0.93, 1.09)	0.93 (0.86, 1.00)	0.18
Cumulative average updated
Person years	162138	187270	152527	118744	71524
Cases	1432	1681	1481	1042	666
Age adjusted HR, 95% CI	1.00	0.99 (0.92, 1.06)	1.04 (0.97, 1.12)	0.94 (0.87, 1.02)	1.00 (0.91, 1.10)	0.61
Multivariate adjusted HR^**, 95% CI	1.00	1.00 (0.93, 1.08)	1.05 (0.97, 1.13)	0.95 (0.88, 1.03)	0.99 (0.90, 1.08)	0.43

The median values of lycopene intake for quintiles 1–5 in 1991 are 3283, 4742, 6064, 8143, and 12511 micrograms/day

^**

Adjusted for age, age at menarche (<10, 11, 12, 13, 14–15, >16), infertility (yes, no), marital status (ever, never), ancestry (white, black, Asian, Hispanic, other), age at first oral contraceptive use (<13, 13–16,17–20,21–24, ≥25), parity (0, 1, 2, 3, >4), age at first birth (<24, 25–30, >30), time since last birth (<1, 1–3, 4–5, 6–7, 8–9, 10–12, 13–15, >16), current BMI (<20, 20–21.9, 22–23.9, 24–24.9, 25–26.9, 27–29.9, >30), diastolic blood pressure (<65, 65–74, 75–84, 85–89, >90), antihypertensive therapy (no, yes), calories (continuous)