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. Author manuscript; available in PMC: 2008 May 21.
Published in final edited form as: Neuron. 2008 Apr 10;58(1):42–51. doi: 10.1016/j.neuron.2008.02.003

Figure 3. Increased glutamate release elevates ISF Aβ levels which requires endocytosis.

Figure 3

(A) ISF A levels in Tg2576 mice treated with dynamin-DN or vehicle followed by LY341495, an mGluR2/3 antagonist that increases pre-synaptic glutamate release. (B) LY341495 increased ISF A levels by 122.2 ± 8.4% during hours 6-8 of treatment (p<0.05, n = 4). The increase in A levels was prevented by pretreatment with dynamin-DN (n = 4). Data presented as mean ± SEM. * represents p<0.05.