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. Author manuscript; available in PMC: 2009 Apr 1.
Published in final edited form as: Structure. 2008 Apr;16(4):558–569. doi: 10.1016/j.str.2008.01.017

Figure 4. Conformational change due to DNA-binding.

Figure 4

Superposition of apo (blue) and DNA-bound (orange) NotI structures for visualization of the conformational change which takes place upon binding of DNA. A decrease in distance between iron atoms of approximately 5.7Å is observed between the two structures, illustrating the motion taking place in the metal-binding and clamp domains. Less movement is observed in the nuclease core and dimerization regions of the structure. The DNA from the DNA-bound structure is colored white and shown for reference.