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. 2008 Mar;3(2):397–406. doi: 10.2215/CJN.00120107

Figure 2.

Figure 2.

Cell surface expression of the macrophage chemokine receptor CCR2, but not CCR1 or CCR5, is significantly lower on blood monocytes from patients with ESRD as compared with blood monocytes from control individuals. Whole blood was collected and stained for CCR1, CCR2 or CCR5 using PE-conjugated antibodies specific for each receptor. All samples were co-stained with CD14-APC to identify monocytes (CD14+). (A) Representative whole blood two-color dot plots for one healthy control, one patient with ESRD (inf−), and one patient with ESRD (inf+). Numbers correspond to MF of chemokine receptor staining in CD14+ monocyte population (identified by dashed boxes). (B through D) Mean monocyte CCR1 (panel B), CCR2 (panel C), and CCR5 (panel D) expression in healthy controls versus patients with ESRD. Data were obtained and analyzed as described in the Statistical Analyses section. The symbol * indicates P < 0.033 versus control.