Table 3.
Plasma chemokine levelsa
| Chemokine | Controls (n = 12) | ESRD (n = 28) | ESRD No Infection (n = 19) | ESRD Recurrent Infection (n = 9) | ESRD Hemodialysis (n = 19) | ESRD Peritoneal Dialysis (n = 9) |
|---|---|---|---|---|---|---|
| MCP-1 | 153 ± 29 | 389 ± 40b | 335 ± 44b | 504 ± 72b | 372 ± 46b | 427 ± 80b |
| MIP-1α | 236 ± 60 | 146 ± 7 | 142 ± 6 | 154 ± 17 | 143 ± 9 | 153 ± 7 |
| MIP-1β | 186 ± 32 | 124 ± 8 | 116 ± 6 | 141 ± 21 | 127 ± 11 | 118 ± 101 |
| RANTES | 1450 ± 225 | 1002 ± 84 | 1003 ± 92 | 999 ± 133 | 1025 ± 102 | 953 ± 157 |
| IL-8 | 658 ± 135 | 414 ± 34 | 366 ± 25 | 516 ± 86 | 411 ± 46 | 420 ± 47 |
Mean values ± SEM from indicated number of control subjects or patients. Chemokine values are reported in pg/ml. Specimens with undetectable chemokine concentrations were assigned a value equal to the lower limit of detection. Significances for control versus ESRD were determined using the Mann–Whitney nonparametric test. Significances for all subgroup analyses were determined using the Kruskal–Wallis nonparametric test followed by pairwise multiple comparisons using the Mann–Whitney test.
P < 0.017 versus control.
MCP-1, monocyte chemotactic protein-1; MIP-1α, macrophage inflammatory protein-1α; MIP-1β, macrophage inflammatory protein-1β; RANTES, regulated upon activation, normal T cell expressed, and secreted protein; IL-8, interleukin-8.