Table 1.
Individual and median gentamicin pharmacokinetic parameter estimates and body weight in study subjects
| Subject No. | Cls (ml/min) | Cld (ml/min) | Vc (L) | Vp (L) | Vss (L) | t1/2β (h) | Weight (kg) |
|---|---|---|---|---|---|---|---|
| 1 | 4.07 | 188 | 5.30 | 9.06 | 14.4 | 41.1 | 75 |
| 2 | 3.84 | 199 | 5.62 | 11.3 | 16.9 | 51.4 | 80 |
| 3 | 2.69 | 95.9 | 3.32 | 5.36 | 8.67 | 37.6 | 37 |
| 4 | 3.94 | 150 | 5.24 | 7.43 | 12.7 | 37.5 | 81 |
| 5 | 3.27 | 195 | 2.69 | 6.31 | 8.99 | 32.0 | 61 |
| 6 | 4.46 | 142 | 4.31 | 8.34 | 12.7 | 33.2 | 84 |
| 7 | 4.81 | 175 | 7.47 | 10.4 | 17.9 | 43.5 | 77 |
| 8 | 3.48 | 240 | 6.61 | 9.47 | 16.1 | 53.6 | 65 |
| Median | 3.89 | 182 | 5.27 | 8.70 | 13.5 | 39.4 | 76 |
Cls, systemic clearance; Cld, distribution clearance between the central and peripheral compartment; Vc, apparent volume of distribution in the central compartment; Vp, apparent volume of distribution in the peripheral compartment; Vss, apparent volume of distribution at steady-state; and t1/2β, terminal elimination half-life (i.e., interdialytic half-life).